The purpose of these studies was to explore the roles of dietary strategies and bariatric surgery in obesity treatment. The breakfast study was a randomized, crossover trial used to evaluate the role of egg proteins, and a retrospective chart review was conducted to obtain comparative information about two different bariatric surgeries. The breakfast study included 20 subjects who were randomized to receive an egg breakfast (EB) or a cereal breakfast (CB) matched for energy density and macronutrient composition but different protein quality for one week. Following a washout period, each subject was crossed over to receive the opposite breakfast for one week. The EB resulted in lower cumulative lunchtime food intake (p=0.05), reduced hunger on day 1 (p=0.001), greater feelings of fullness on days 1 and 7 (p=0.02), and decreased desire to eat on day 1 (p=0.03). Acylated ghrelin was lower on day 1 of the EB compared to the CB (p=0.005) but not on day 7. PYY was greater at 120 minutes (p=0.006) and 180 minutes (p=0.001) on day 1 and at 180 minutes on day 7 (p=0.03) after the EB. The bariatric surgery studies examined 835 Roux-en-Y gastric bypass (RYGB) patients and 766 vertical sleeve gastrectomy (VSG) patients. Study one focused on patients diagnosed with type 2 diabetes (T2D). The acute effect bariatric surgery had on resolving T2D was measured by calculating the number of patients who discontinued their hypoglycemic medication use post-operatively. Upon discharge, 95 of the 123 (77.2%) RYGB patients and 107 of the 139 (77.0%) VSG patients had been taken off their medication. Eight weeks post-operatively, 30 of the 38 (~79%) RYGB patients and 59 of the 71 (83%) VSG patients with follow-up data remained off medication. Study two examined differences in weight loss, early post-operative surgical complications, and insurance coverage between RYGB and VSG patients. RYGB patients lost more weight at one and two years (p<0.001 for both). There was no significant difference in the percentage of weight loss or complications in insured versus self-pay patients. RYGB patients experienced a higher incidence of major complications than VSG patients (p<0.001).
| Identifer | oai:union.ndltd.org:LSU/oai:etd.lsu.edu:etd-10312011-102824 |
| Date | 31 October 2011 |
| Creators | Bayham, Brooke Erwin |
| Contributors | Tuuri, Georgianna, O'Neil, Carol, Greenway, Frank |
| Publisher | LSU |
| Source Sets | Louisiana State University |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lsu.edu/docs/available/etd-10312011-102824/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached herein a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to LSU or its agents the non-exclusive license to archive and make accessible, under the conditions specified below and in appropriate University policies, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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