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Magnetic resonance imaging and magnetic resonance spectroscopy characterize a rodent model of covert stroke

Covert stroke (CS) comprises lesions in the brain often associated by risk factors such as a diet high in fat, salt, cholesterol and sugar (HFSCS). Developing a rodent model for CS incorporating these characteristics is useful for developing and testing interventions. The purpose of this thesis was to determine if magnetic resonance (MR) can detect brain abnormalities to confirm this model will have the desired anatomical effects. Ex vivo MR showed brain abnormalities for rats with the induced lesions and fed the HFSCS diet. Spectra acquired on the fixed livers had an average percent area under the fat peak relative to the water peak of (20±4)% for HFSCS and (2±2)% for control. In vivo MR images had significant differences between surgeries to induce the lesions (p=0.04). These results show that applying MR identified abnormalities in the rat model and therefore is important in the development of this CS rodent model.

Identiferoai:union.ndltd.org:MANITOBA/oai:mspace.lib.umanitoba.ca:1993/13691
Date17 December 2012
CreatorsHerrera, Sheryl Lyn
ContributorsMartin, Melanie (Physics and Astronomy) Bidinosti, Chris (Physics and Astronomy), Elhami, Esmat (Physics and Astronomy) Lin, Francis (Physics and Astronomy) Civetta, Alberto (Biochemistry & Medical Genetics)
Source SetsUniversity of Manitoba Canada
Detected LanguageEnglish

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