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Effects of dietary oils low in n-6:n-3 fatty acid ratio on cardiovascular risk in mice: the impact of the source of n-3 fatty acids

The impact of the source of n-3 fatty acids on cardiovascular disease has not been fully investigated. This study was carried out to investigate cardiovascular benefits of diets with a low ratio (2:1) of n-6:n-3 fatty acids from different sources, either fish or flaxseed oil, in C57BL/6 mice. Twenty-one mice were divided into 3 groups (n=7) and fed an atherogenic diet supplemented with either a fish or flaxseed oil-based ‘designer oil’ with low n-6:n-3 fatty acid ratio (treated groups) or safflower oil-based formulation with a high ratio (control group) for 16 weeks. Plasma cholesterol levels declined significantly in both treated groups, by greater than 30%, compared to those in control. The ratio of n-6:n-3 fatty acids in liver was significantly lower in fish and flax groups as compared to control. Our data suggest that lowering dietary ratio of n-6:n-3 fatty acids may significantly reduce cardiovascular risks regardless of the source of n-3 fatty acids.

Identiferoai:union.ndltd.org:MANITOBA/oai:mspace.lib.umanitoba.ca:1993/3090
Date16 September 2008
CreatorsRiediger, Natalie Diane
ContributorsMoghadasian, Mohammed (Human Nutritional Sciences), Suh, Miyoung (Human Nutritional Sciences) Friel, James (Human Nutritional Sciences) Beta, Trust (Food Science)
Source SetsUniversity of Manitoba Canada
Languageen_US
Detected LanguageEnglish

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