Return to search

Gene Expression Profiling in Surrogate Tissues to Identify Biomarkers Following Conazole Exposure

Conazoles are a class of azole fungicides which are used for agricultural and pharmaceutical applications. This study examined two conazoles that possess a range of reproductive, carcinogenic, and neurodevelopmental effects. Sprague-Dawley rats were dosed daily by oral gavage for 14 days with triadimefon (5 or 115 mg/kg/day) or myclobutanil (10 or 150 mg/kg/day). Relative liver weight increased following high dose triadimefon and myclobutanil exposure. Weight changes were not observed in testes, nor were there significant changes in serum testosterone levels. Microarray analysis of 4,370 genes yielded forty-eight differentially expressed genes in blood. Of these, nine genes were found to be concordant with liver and testis gene expression data.

Identiferoai:union.ndltd.org:NCSU/oai:NCSU:etd-11032004-105732
Date01 December 2004
CreatorsMurrell, Rachel N.
ContributorsErnest Hodgson, John C. Rockett, David J. Dix
PublisherNCSU
Source SetsNorth Carolina State University
LanguageEnglish
Detected LanguageEnglish
Typetext
Formatapplication/pdf
Sourcehttp://www.lib.ncsu.edu/theses/available/etd-11032004-105732/
Rightsunrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to NC State University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.

Page generated in 0.0023 seconds