Background : The oral administration of Glucosamine and intra-articular (IA) injection of
Hyaluronic Acid were used to treat osteoarthritis. Several studies supported that clinical pain
symptoms could be alleviated, and activities of daily life improved after the completion of IA knee
hyaluronic acid injections. However, the efficacy of oral administration of Glucosamine was
inconclusive. In Taiwan, the Taiwan's National Health Insurance (NHI) made the strict formulations
for the both of ¡§oral administration of Glucosamine ¡§and ¡§IA knee hyaluronic acid injections.¡¨ But,
there were no evidence to prove that whether the combined treatments from both oral
administration of Glucosamine and IA knee hyaluronic acid injections were more effective than the
treatment with the IA knee hyaluronic acid injections alone.
Objectives : The porpose of this study was to examine whether the effects of treatment combined
with both ¡§oral administration of Glucosamine and IA knee hyaluronic acid injections¡¨ on clinical
pain symptoms and activities of daily living were better than ¡§IA knee hyaluronic acid injections¡¨
alone.
Methods : We randomly assigned 60 patients with symptomatic knee osteoarthritis, at the
department of Orthopedics, Kaohsiung Municipal Union Hospital, between 2008 and 2009, to
receive oral administration of Glucosamine and IA knee hyaluronic acid injections or oral
administration of Placebo and IA knee hyaluronic acid injections. In this study, clinical pain
symptoms, and activities of daily living were assessed by using Lequesne's Index, visual analogue
scale index, Berg Balance Test, and Biodex Balance Test before and after the treatment in 60
patients with the knee OA.
Result : The mean age was 66.6 years, and 70 percent were woman. There was a significant
efficacy before and after treatments both in the treatment group(p<0.001) and the placebo control
group(p<0.001). In the other hand, there was not the statistical significance in the efficacy between
the treatment group and the control group(p=0.869).
Conclusion : The combined treatment with both oral administration of Glucosamine and IA knee
hyaluronic acid injections was not significantly better than the IA knee hyaluronic acid injections
alone in reducing knee pain or promoting the function of daily life.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0615109-173914 |
| Date | 15 June 2009 |
| Creators | Yen, Chia-Chi |
| Contributors | Meng-Chiao Lin, Shu-Chuan Jennifer Yeh, Ying-Chun Li |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0615109-173914 |
| Rights | unrestricted, Copyright information available at source archive |
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