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Studies on the loop II coordinate structure of long £\-neurotoxins

Six new structural parameters £rB, £pB, £rC, £pC, £rS, and £pS are proposed to enhance the side chain actions in protein structures. Programs for calculating these new parameters based on phi and psi torsion angles vector algebra calculation method are established. A bivariate model with von Mises marginal distributions are applied to establish models of phi and psi in protein class Ophiophagus hannah neurotoxins and alpha-bungarotoxins respectively. 11 global structural parameters include phi and psi torsion angles, bond lengths of C-N, C-O, C£\ -C, and N-C£\, and bond angles of C-N-C£\, C£\-C-N, C£\-C-O, N-C£\-C, and O-C-N are considered to classify long alpha-neurotoxins by Ward's cluster method and LIBSVM program package. Those global structural parameters of loop II Trp residues of alpha-neurotoxins are discussed.

Identiferoai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0716102-172715
Date16 July 2002
CreatorsFeng, Wen-Ying
ContributorsGrace Shwu-Rong Shieh, Mei-Hui Guo, Rong-I Hong, Shangwu (Sam) Ding, L.S. Chang
PublisherNSYSU
Source SetsNSYSU Electronic Thesis and Dissertation Archive
LanguageEnglish
Detected LanguageEnglish
Typetext
Formatapplication/pdf
Sourcehttp://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0716102-172715
Rightsunrestricted, Copyright information available at source archive

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