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Using Simulated Annealing Method to Resolve the Structure of Myoglobin

The £\-helix structure of protein is very similar to the cylindrical structure. Especially, the Sperm-Whale Myoglobin molecules has 70% £\-helix structure. Therefore, we use simulated annealing method to solve ¡§X-ray phase problem¡¨, and apply Metropolis algorithm to avoid local minimum. We hope that the new method can build £\-helix structure of Sperm-Whale Myoglobin molecule.
Therefore, we use multi cylinders as the Myoglobin¡¦s tertiary structure and solve the cylinder¡¦s structure with the simulated annealing method.

Identiferoai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0717102-154451
Date17 July 2002
CreatorsChen, Chien-Cheng
ContributorsHerng-Yih Ueng, Wang-Chuang Kuo, Chiang Michael Yen-Nan
PublisherNSYSU
Source SetsNSYSU Electronic Thesis and Dissertation Archive
LanguageCholon
Detected LanguageEnglish
Typetext
Formatapplication/pdf
Sourcehttp://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0717102-154451
Rightswithheld, Copyright information available at source archive

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