In the organism, genes don¡¦t work independently. The interaction of genes shows how the functional task affects. Observing the interaction can understand what the relation between genes and how the disease caused. Several methods are adopted to observe the interaction to construct gene relation network. Existing algorithms to construct gene relation network can be classified into two types. One is to use literatures to extract the relation between genes. The other is to construct the network, but the relations between genes are not described. In this thesis, we proposed a hybrid method based on these two methods. Bayesian network is applied to the microarray gene expression data to construct gene network. Text mining is used to extract the gene relations from the documents database. The proposed algorithm integrates gene network and gene relations into gene relation networks. Experimental results show that the related genes are connected in the network. Besides, the relations are also marked on the links of the related genes.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0911107-172439 |
| Date | 11 September 2007 |
| Creators | Chen, Shu-fen |
| Contributors | Chungnan Lee, Yen-Ting Chen, Cha-Hwa Lin, Shiue, Yow-Ling, Cheng-Wen Ko |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0911107-172439 |
| Rights | not_available, Copyright information available at source archive |
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