This investigation was conducted to determine the
effect of estrogen replacement therapy (ERT) on vitamin B-6
status of postmenopausal women. Nineteen postmenopausal
women served as subjects. Nine (54.7 + 4.7 years) were
taking ERT (experimental group); ten (56.8 + 2.3 years)
were not (control group). For three consecutive days,
subjects recorded their dietary intake and collected their
24-hour urine specimens. On the fourth day, a fasting
blood sample was drawn from the subjects. The dietary
intake of vitamin B-6, as well as the concentration of
total vitamin B-6 in plasma (PB6; and urine (UB6) were
measured. PB6 and UB6 were determined by a microbiological
method with Saccharomyces uvarum as the assay organism.
The mean age, height, hematocrit and hemoglobin values
were similar for the two groups. The experimental group
was significantly heavier than the control group (p<0.05).
The experimental group had a lower mean PB6 than the
control group: 47.7 ± 19.7 nmol/L vs. 56.2 + 20.6 nmol/L.
These means were not significantly different (p=0.05). PB6
was positively correlated with dietary vitamin B-6 intake
(p=0.0001) and vitamin B-6 to protein ratio (p=0.0021).
When the means were adjusted for dietary vitamin B-6 and
the vitamin B-6 to protein ratio, the mean PB6 of the
experimental group (42.7 nmol/L) was significantly lower
than that of the control group (60.6 nmol/L) (p<0.05). PB6
was not positively correlated with either age (r=0.20) or
the vitamin B-6 dietary history score (r=0.15).
UB6 was similar for the two groups. UB6 correlated
positively with daily dietary intake of vitamin B-6
(r=0.51, p<0.05) and the ratio of vitamin B-6 to protein
(r=0.47, p<0.05), UB6 was not significantly correlated to
urine volume (r=0.05).
The mean daily intakes of vitamin B-6 and protein were
similar for the two groups. One of the 19 subjects had a
vitamin B-6 intake that was less than 67 percent of the
RDA. Most subjects' (89%) intake of vitamin B-6 was
adequate when the ratio of 0.016 mg of vitamin B-6 per g of
protein was used as the standard. / Graduation date: 1990
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/27135 |
| Date | 16 March 1990 |
| Creators | Harris, Janet Elizabeth |
| Contributors | Miller, Lorraine T. |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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