The effect of dietary glycosylated vitamin B-6 on the bioavailability
of vitamin B-6 was determined in 4 women. A 44-d metabolic-balance diet
study was divided into a preliminary 8-d adjustment period followed by
two 18-d experimental periods. The subjects were divided into two groups
in a crossover design to compare the effect of low- and high-glycosylated
vitamin B-6 diets on the bioavailability of vitamin B-6. The total vitamin
B-6 content in the low- and high-glycosylated vitamin B-6 diets was 1.506
mg (8.91 nmol) and 1.897 mg (11.22 μmol), respectively, in which 11 and
22% was the glycosylated form, respectively. Daily 24-h urine specimens
were collected by each subject throughout the study; 7- or 8-d fecal
collections were made at the end of each experimental period. The four
subjects' mean urinary total vitamin B-6 excretion during the low- and
high-glycosylated vitamin B-6 periods was 0.76 ± 0.20 and 0.67 ± 0.06
μmol/24 h, respectively; fecal total vitamin B-6 excretion was 2.98 ± 0.43
and 4.56 ± 0.87 μmol/24 h, respectively. Expressed as % of total vitamin B-6 intake, the mean urinary total vitamin B-6 excretion was lower during the
high-glycosylated vitamin B-6 period (6.0 ± 0.8%) than during the low-glycosylated
vitamin B-6 period (8.5 ± 2.4%); in contrast, their mean fecal
vitamin B-6 excretion during the high-glycosylated vitamin B-6 period
(40.7 ± 8.2%) was greater than the low-glycosylated vitamin B-6 period (33.6
± 5.4%). In addition, approximately 11% of ingested glycosylated vitamin
B-6 was excreted in urine. These results suggest that dietary glycosylated
vitamin B-6 is not completely bioavailable to humans, and the extent of its
utilization is not affected by dietary glycosylated vitamin B-6 intake. / Graduation date: 1993
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/27185 |
| Date | 13 May 1992 |
| Creators | Chen, Wen-shan Chou, 1964- |
| Contributors | Miller, Lorraine T. |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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