The present study investigated whether vitamin E supplementation reduced
oxidative stress in erythrocytes and improved vitamin E status in patients
undergoing hemodialysis (HD). Plasma and erythrocyte α-tocopherol, plasma
ascorbic acid, and iron status were determined in 11 regular HD patients prior to
and post-dialysis, before and during oral supplementation of vitamin E, 400 IU
daily for two months. HD patients were categorized into two groups according to
their plasma ascorbic acid levels. We found that only the vitamin C sufficient group
(>40 μM, Group I) had reliable measurements of erythrocyte α-tocopherol
concentrations before vitamin E supplementation. In Group I prior to dialysis,
erythrocyte α-tocopherol concentrations increased in response to vitamin E
supplementation from 6.7 ± 0.7 μmol/L packed cells to 9.8 ± 0.6 (μmol/L packed
cells (p<0.04). Moreover, there was a positive correlation (p<O.001) between
plasma and erythrocyte α-tocopherol levels in Group I subjects. Additionally,
vitamin E supplementation significantly increased hematocrits (39.9% ± 1.9% to
42.3% ±1.6%, p<0.004) post-dialysis only in Group I subjects. On the contrary,
there was no change in hematocrits during vitamin E supplementation in the vitamin C deficient group (<40 μM, Group II). With respect to measures of iron
status and recombinant human erythropoietin (rHuEPO) dose, no differences
between before and during vitamin E supplementation were observed in two groups
ofpatients. In summary, our data suggest that oral vitamin E supplementation
protected erythrocytes from oxidative stress and improved vitamin E status in HD
patients, but only in patients with adequate vitamin C status. / Graduation date: 2003
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/27225 |
| Date | 14 August 2002 |
| Creators | Lee, Chia-Lin |
| Contributors | Traber, Maret G. |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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