Reported here is an investigation to determine the in vitro and in vivo metabolism
of xanthohumol (XN). XN is the major prenylated flavonoid of the female
inflorescences (cones) of the hop plant (Humulus lupulus). It is also a constituent of
beer, the major dietary source of prenylated flavonoids. Recent studies have
suggested that XN may have potential cancer chemopreventive activity but little is
known about its metabolism. We investigated the in vitro metabolism of XN by rat
and human liver microsomes, and cDNA-expressed cytochrome P450s, and the in
vivo metabolism of XN by rats. The metabolites and conjugates were identified by
using high-pressure liquid chromatography, liquid chromatography-mass
spectrometry, and nuclear magnetic resonance. The antioxidant properties of two
metabolites and two glucuronides were examined. The possible risk of XN
consumption from beer or dietary supplements is discussed. The involvement of
metabolites of XN in cancer chemoprevention remains to be established. / Graduation date: 2001
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/32605 |
| Date | 05 January 2001 |
| Creators | Yilmazer, Meltem |
| Contributors | Buhler, Donald R. |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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