The disposition of four therapeutically important antimicrobial agents
was studied in llamas following intravenous bolus administration. Six llamas were
each given ampicillin, tobramycin, trimethoprim and enrofloxacin at a dose of 12
mg/kg, 1 mg/kg, 3 mg/kg and 5 mg/kg of body weight with a wash out period
of 3 days between each treatment. Plasma concentrations of these antimicrobial
agents over 12 hours following IV bolus dosing were determined by reverse
phase HPLC. Dispositions of these four antimicrobial agents were described by
two compartment open model with elimination from the central compartment,
and also by non-compartmental methods. From compartmental analysis, the
elimination rate constant, half-life, and apparent volume of distribution in the
central compartment were determined. Statistical moment theory was used to
determine non-compartmental pharmacokinetic parameters of mean residence
time, clearance, and volume of distribution at steady-state. Based on the
disposition parameters determined, a dose and dosing interval for each of the
four antimicrobial agents was suggested for llamas. Steady state peak and trough
plasma levels were also predicted for the drugs in this study for llamas. / Graduation date: 1994
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/35890 |
| Date | 05 January 1994 |
| Creators | Murdande, Sharad B. |
| Contributors | Christensen, J. Mark |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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