Sustained concentrations of active compound were maintained
in vitro and in vivo for an oral and a parenteral dosage form
respectively. The vehicle of a oral dosage form was modified and the
molecular structure of a parenteral dosage form was modified. An oral
dosage form was tested in vitro using dissolution apparatus. A
parenteral dosage form was tested in vivo using rats.
A new oral suspension dosage form for acetylsalicylic acid was
compared to two controlled release forms and two immediate release
dosage forms which are currently commercially available. A parenteral
thrombomodulin analogue conjugated to polyethylene glycol was
compared to the unconjugated thrombomodulin analogue. In each
case the goal was to maintain sustained concentrations of active
compound. / Graduation date: 1991
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/37514 |
| Date | 16 April 1991 |
| Creators | Piepmeier, Edward H. |
| Contributors | Christensen, J. Mark |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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