El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado. / Insulin resistance is common among obese adolescents; however, the extent of this problem is not clear. We conducted a systematic review of PubMed-Medline, CINAHL, The Web of Science, EMBASE and Scopus for observational studies evaluating components defining insulin resistance (insulin, C-peptide and homeostatic model assessment-insulin resistance [HOMA-IR]) in obese adolescents (12–18 years) versus non-obese adolescents. Our systematic review and meta-analysis followed the PRISMA guidelines. Data were combined using a random-effects model and summary statistics were calculated using the mean differences (MDs). 31 studies were included (n = 8655). In 26 studies, fasting insulin levels were higher in obese adolescents when compared to non-obese adolescents (MD = 64.11 pmol/L, 95%CI 49.48–78.75, p < 0.00001). In three studies, fasting C-peptide levels were higher in obese adolescents when compared to non-obese adolescents (MD = 0.29 nmol/L, 95%CI 0.22–0.36, p < 0.00001). In 24 studies, HOMA-IR values were higher in obese adolescents when compared to non-obese adolescents (MD = 2.22, 95%CI 1.78–2.67, p < 0.00001). Heterogeneity of effects among studies was moderate to high. Subgroup analyses showed similar results to the main analyses. Circulating insulin and C-peptide levels and HOMA-IR values were significantly higher in obese adolescents compared to those non-obese. / Revisión por pares
| Identifer | oai:union.ndltd.org:PERUUPC/oai:repositorioacademico.upc.edu.pe:10757/622281 |
| Date | 19 January 2017 |
| Creators | Thota, P., Perez-Lopez, F. R., Benítes-Zapata, Vicente A., Pasupuleti, V., Hernandez, Adrian V. |
| Contributors | School of Medicine, Case Western Reserve University, Cleveland, OH, USA,, Department of Obstetrics and Gynecology, University of Zaragoza Faculty of Medicine and Lozano Blesa University Hospital, Domingo Miral s/n, Zaragoza, Spain,, Center for Public Health Research, Research Institute, Faculty of Medicine, University of San Martin de Porres, Lima, Peru,, School of Medicine, Case Western Reserve University, Cleveland, OH, USA,, School of Medicine, Universidad Peruana de Ciencias Aplicadas (UPC), Lima, Peru, and, adrianhernandezdiaz@gmail.com |
| Publisher | Taylor and Francis Ltd |
| Source Sets | Universidad Peruana de Ciencias Aplicadas (UPC) |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/article |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/restrictedAccess |
| Relation | https://www.tandfonline.com/doi/full/10.1080/09513590.2016.1273897 |
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