The primary objective of the study is to assemble population pharmacokinetic models from the cancer pharmacokinetics literature for different types of anti-cancer drugs and to formulate them in ways suitable for input into cancer simulation programs.
To fulfill the objectives, a step-based approach is adopted:
1)To catalogue the types of pharmacokinetic models through general review articles and books
2)To develop a search strategy for defining a body of research literature related to cancer pharmacokinetics in clinical trials for a limited set of drugs (Taxol, Platinum compounds. Fluoropyrimidine and Topoisomerase inhibitors)
3)To collect pharmacokinetic articles according to defined search criteria
4)To gather information from the collected PK articles
5)To synthesize the information separately for each drug, using a questionnaire instrument and present them in template form for each class of antineoplastic agent.
6)To formulate population pharmacokinetic models for each anti-cancer drug, from the constituent submodels for components of the overall model.
This work will promote public health, specifically in support of the development of anti-cancer drug regimens for cancer patients, by
providing standardized information about pharmacokinetics for input into simulations.
| Identifer | oai:union.ndltd.org:PITT/oai:PITTETD:etd-05182004-093517 |
| Date | 21 May 2004 |
| Creators | Radhakrishnan, Rajkumar |
| Contributors | Yookyung Kim, Douglas Landsittel, Roger S. Day, Barry R. Stripp |
| Publisher | University of Pittsburgh |
| Source Sets | University of Pittsburgh |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.pitt.edu/ETD/available/etd-05182004-093517/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to University of Pittsburgh or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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