Radiological imaging of the liver is an important medical problem. The ever increasing amount of data acquired when imaging the liver makes integration of information desirable and crucial in building up a comprehensive diagnostic picture of the patient. The foundation of all such image integration is image registration.
</br></br>Image registration is the process of aligning images so that corresponding features can easily be related, including: (1) landmark-driven methods, (2) surface-based methods, and (3) voxel similarity-based methods. A challenge with registering the liver is that the liver moves within the abdomen with respiration. Therefore any effective alignment of the liver must first separate the liver from the remainder of the image. With this as a constraint, the goal of this research effort was to determine the feasibility and efficacy of surface-based and voxel similarity-based schemes in registering abdominal CT and MR images with and without contrast.
</br></br>A multi-scale surface fitting technique was implemented based on the Head and Hat algorithm. Equivalent surfaces from the in vivo images were extracted manually. The hand segmentation approach was validated by ensuring the volume of the liver of each image from the same patient was consistently within +/- 7% of one another. The registration transformation was determined by iteratively transforming the hat with respect to the head surface, until the closest fit of the hat onto the head was found.
</br></br>In addition, registration of in vivo CT and MR images was performed using a multi-resolution mutual information scheme distributed with the ITK Insight software package (National Library of Medicine, Bethesda, MD). As an independent measure of registration accuracy, the mean displacement of automatically selected point landmarks was evaluated. For the multi-resolution mutual information approach, mean misregistrations were in the range of 7.7-8.4mm for CT-CT intramodality registration, 8.2mm for MR-MR intramodality registration, and 14.0-18.9mm for CT-MR intermodality registration. For the Head and Hat surface registration scheme, mean misregistrations were in the range of 9.6-11.1mm for CT-CT intramodality registration, 9.2-12.4mm for MR-MR intramodality registration, and 15.2-19.0mm for MR-CT intermodality registration.
| Identifer | oai:union.ndltd.org:PITT/oai:PITTETD:etd-12022003-131104 |
| Date | 02 February 2004 |
| Creators | Lee, Wen-Chi Christina |
| Contributors | Brian E. Chapman, George D. Stetten, Fernando E. Boada |
| Publisher | University of Pittsburgh |
| Source Sets | University of Pittsburgh |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.pitt.edu/ETD/available/etd-12022003-131104/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to University of Pittsburgh or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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