Background: Polycystic ovary syndrome (PCOS) is a common complex hormonal disorder. Many PCOS symptoms may have implications on bone mineral density (BMD). One way to analyze BMD is quantitated computed tomography (QCT), which may have advantages over other BMD analysis methods. The study analyzed descriptive characteristics of a group of PCOS cases and controls; considered the determinants of BMD (as measured by QCT) from the literature in PCOS cases and controls; and adjusted for these variables via multivariate logistic regression to determine if PCOS case status is an independent predictor of lumbar BMD after controlling for these factors. Methods: The study used women from the third implementation of the University of Pittsburgh Cardiovascular Health and Risk Management study (CHARM III). Descriptive information was gathered by survey and clinical visits and blood samples were taken to measure hormones and other biological factors. Lumbar BMD was measured by QCT in a subset of women. Students T-Test, the Mann-Whitney U-Test and X2 tests were used to evaluate descriptive characteristics of PCOS cases and controls. BMD measures between PCOS case and controls were compared using Students T-test. Lumbar BMD comparisons between PCOS cases and controls were also stratified by factors determined from the literature to affect BMD, including age, ethnicity, menstrual period status, BMI, and menstrual history. Correlations of BMD with hormones in cases and controls were considered. Multivariate linear regression models were used to assess the effect of PCOS case-control status on lumbar BMD after controlling for these factors associated with BMD. Results: There was no significant BMD difference between PCOS cases and controls for any univariate comparisons, nor for any multivariate adjusted compositions. Conclusion: The deleterious effects of middle age and approaching menopause and the protective effects of heavy BMI in controls may mediate some protective effects of PCOS case status on BMD in this group. Statement of Public Health Significance: The current study is one of only a few to use QCT to measure BMD in women with PCOS. Results from this study can serve as the basis of comparison for other studies that use QCT methods to assess BMD.
| Identifer | oai:union.ndltd.org:PITT/oai:PITTETD:etd-12062007-134312 |
| Date | 31 January 2008 |
| Creators | McCleary, Lara |
| Contributors | Dr. Jane Cauley, Dr. John Wilson, Dr. Evelyn Talbott |
| Publisher | University of Pittsburgh |
| Source Sets | University of Pittsburgh |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.pitt.edu/ETD/available/etd-12062007-134312/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to University of Pittsburgh or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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