Antiplasmodial and larvicidal flavonoids from Derris trifoliata

From the dichloromethane-methanol (1:1) extract of the seed pods of Derris trifoliata, a new flavanone derivative (S)-lupinifolin 4´-methyl ether was isolated. In addition, the known flavonoids lupinifolin and rotenone were identified. The structures were determined on the basis of spectroscopic evidence. Lupinfolin showed moderate in vitro antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquineresistant)
strains of Plasmodium falciparum. The different parts of this plant showed larvicidal activities against Aedes aegypti and rotenoids were identified as the active principles.

Identiferoai:union.ndltd.org:Potsdam/oai:kobv.de-opus-ubp:4461
Date January 2009
CreatorsPeter, Martin G., Yenesew, Abiy, Twinomuhwezi, Hannington, Kabaru, Jacques M., Akala, Hoseah M., Kiremire, Bernard T., Heydenreich, Matthias, Eyase, Fredrick, Waters, Norman C., Walsh, Douglas S.
PublisherUniversität Potsdam, Mathematisch-Naturwissenschaftliche Fakultät. Institut für Chemie
Source SetsPotsdam University
LanguageEnglish
Detected LanguageEnglish
TypePostprint
Formatapplication/pdf
SourceBulletin of the Chemical Society of Ethiopia 23 (2009), 3, S. 409 - 414
Rightshttp://opus.kobv.de/ubp/doku/urheberrecht.php, Volltextzugriff: Universitätsverlag - eingeschränkter Zugriff

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