The activity of the growth cone is necessary for neuron axon elongation during neuron development and regeneration. This is a highly dynamic process of cytoskeletal recorganization that requires a significant amount of energy provided by the mitochondria. The localization of a sufficient number of mitochondria at the growth cone is essential to support its activity during neuron development and regeneration. Both promotion and inhibition of the motility of growth cones can be induced by intrinsic factors of neuron itself such as cytoskeleton dynamics and motor protein activity, as well as extracellular molecules in the vicinity of the neuron such as nerve growth factor (NGF) and components of the extracellular matrix. The proposed hypothesis is that some of these factors have an impact on the localization and morphology of mitochondria. My work in this project is aimed to determine which of these factors have the greatest impact on mitochondria in neurons. Using sensory neurons isolate / Biomedical Sciences
| Identifer | oai:union.ndltd.org:TEMPLE/oai:scholarshare.temple.edu:20.500.12613/3872 |
| Date | January 2017 |
| Creators | Xu, Zhuxuan |
| Contributors | Gallo, Gianluca, Gallo, Gianluca, Kim, Seonhee, Langford, Dianne |
| Publisher | Temple University. Libraries |
| Source Sets | Temple University |
| Language | English |
| Detected Language | English |
| Type | Thesis/Dissertation, Text |
| Format | 89 pages |
| Rights | IN COPYRIGHT- This Rights Statement can be used for an Item that is in copyright. Using this statement implies that the organization making this Item available has determined that the Item is in copyright and either is the rights-holder, has obtained permission from the rights-holder(s) to make their Work(s) available, or makes the Item available under an exception or limitation to copyright (including Fair Use) that entitles it to make the Item available., http://rightsstatements.org/vocab/InC/1.0/ |
| Relation | http://dx.doi.org/10.34944/dspace/3854, Theses and Dissertations |
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