Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder. Cortical thinning of the anterior mid-cingulate cortex (aMCC) and insula has been previously reported in IBS (Davis et al., 2008). The aim of the present study was to examine cortical and subcortical structural gray matter integrity in IBS with particular attention to individual disease symptoms and personality characteristics such as pain catastrophizing. Eleven IBS patients and 16 age-matched healthy subjects (female, right-handed) underwent structural MRI. Voxel Based Morphometry and Cortical Thickness Analysis revealed that the IBS group had increased gray matter density in the hypothalamus, cortical thinning in the aMCC, strong (r = -66; p=0.015), a negative correlation between dorsolateral prefrontal cortex and pain catastrophizing and anterior insula thickness was positively correlated to pain duration (r = 0.77, p=0.003) when controlling for age. These abnormalities may contribute to chronic pain in IBS.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/18161 |
| Date | 16 December 2009 |
| Creators | Blankstein, Udi |
| Contributors | Davis, Karen |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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