Introduction: To evaluate the effectiveness of smoking cessation intervention, reliable
outcome is essential. Exhaled nitric oxide (ENO) is decreased in smokers, tends to
normalize after cessation and might be a good tool to evaluate abstinence. Objective: To
evaluate changes in ENO after smoking abstinence of 7 or more days. Methods: 58
smokers in a cessation attempt and 12 non-smokers were recruited: 7 visits for smokers
and 2 for non-smokers. Carbon monoxide and cotinine were used to detect smoking
status. Results: ENO is decreased in smokers compared to non-smokers (10.8 vs. 20.1
ppb, p<0.001). There was no significant difference in ENO pre and post quitting
(p=0.080) although there was a trend to increase as early as 3 days after abstinence
(10.78 vs. 15.11, p>0.05). There were no differences in nasal NO measurements
(p=0.278). Conclusion: ENO doesn’t seem to be a reliable marker of short-term
abstinence.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/24241 |
| Date | 06 April 2010 |
| Creators | Barreto, Renata |
| Contributors | Chapman, Kenneth |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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