The following study investigates the intramolecular and intermolecular interactions responsible
for invoking stereoselectivity and stereospecificity in the synthesis of a chiral original species and amino
acid receptor. The former commences with a brief overview of the nature, scope and applications of
helical chirality, and culminates in the formation of a permanent helix via the synthesis of a novel chiral
lactone. The latter is discussed as an extension of a naturally occurring cofactor whose identity is
modulated to furnish a tailored receptor selective to the binding of amino-acid enantiomers. The study
and analysis is executed via both synthetic and computational methods.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/25598 |
| Date | 31 December 2010 |
| Creators | Golas, Ewa |
| Contributors | Chin, Jik |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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