This thesis assessed whether advantages existed for animal (calcium caseinate) versus vegetable protein (barley protein-enriched flour) foods when fed at 30 g protein per day to 23 healthy hyperlipidemic subjects for 4 weeks in a randomized crossover study. Outcomes included serum lipids, serum markers of oxidative stress and the growth response of LNCaP prostate and MCF-7 breast cancer cells when incubated in vitro with individual subject’s study serum as an indication of whether the treatment promoted or inhibited cell growth. There was no treatment effect on blood lipids or biomarkers of oxidative stress nor was in vitro cell growth different between treatments. However, after pooling the two treatments, both MCF-7 and LNCaP cell growth was related positively to the change in oxidized LDL. MCF-7 growth was negatively related to the non-HDL-C: HDL-C ratio suggesting that raising intracellular cholesterol and reducing oxidative stress may have preventive and possibly therapeutic advantages.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/25808 |
| Date | 11 January 2011 |
| Creators | Srichaikul, Korbua (Kristie) |
| Contributors | Jenkins, David J. A. |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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