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Imaging Biomarkers of Response to Radiation and Anti-angiogenic Agents in Brain Tumors

There is mounting evidence to support combined therapy with radiation (RT) and antiangiogenic agents (AA) for the treatment of brain tumors. However, the therapeutic benefit of this combined treatment hinges on the specific dose, schedule, and duration of each treatment. Early biomarkers that reflect tumor physiological responses provide key information that could guide these aspects of treatment. Pre-clinical tumor models are invaluable tools for identifying potential biomarkers, their optimal timing for measurement and their ability to guide therapy in clinical translation. This thesis demonstrates the feasibility and potential of serial MRI to guide the design, delivery and measure of early response to combined AA and RT in a murine intracranial glioma model. We identified promising biomarker changes reflecting early treatment response that may ultimately facilitate individualized spatio-temporal delivery of radiotherapy (RT) and anti-angiogenic agents (AA) for brain tumors.

Identiferoai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/27330
Date30 May 2011
CreatorsChung, Caroline
ContributorsMenard, Cynthia
Source SetsUniversity of Toronto
Languageen_ca
Detected LanguageEnglish
TypeThesis

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