Percutaneous coronary revascularization of chronic total occlusions (CTOs) is difficult due to the presence of a hard proximal fibrous cap and lack of image guidance. The use of x-ray fluoroscopy alone makes it difficult to identify vessel boundaries and occlusive constituents which would aid the process of revascularization. It also can be difficult to keep a guidewire intraluminal without puncturing the vessel wall. Although several imaging modalities are being developed, a technique for measuring the stiffness of occlusions would facilitate revascularization by helping the process of guidewire selection and placement. In this study, a technique known as static magnetic resonance elastography is explored as a method of determining the compliance of CTOs. A finite element simulation was used to determine the response of an artery to deformation, and displacement images were obtained from an artery phantom using a stimulated echo MR imaging pulse sequence and a pneumatic compression system.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/31273 |
| Date | 12 December 2011 |
| Creators | Kates, Brian S. |
| Contributors | Wright, Graham |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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