Vigabatrin (VGB) is an anti-epileptic drug used to treat children with Infantile Spasms (IS). The 3.0 flicker amplitude of the electroretinogram (ERG) is currently used to monitor visual function changes in infants on VGB. To find a more specific marker of permanent changes due to VGB, sedated ERGs were performed on 31 IS patients and 13 retinally normal controls to isolate components of the cone pathway. ERG growth curves, for each component, recorded from children with IS were generated using data recorded pre-VGB treatment and for controls. Only the cone off response (from Off bipolar cells) and cone photoreceptor sensitivity were associated with decreased flicker amplitude. Twenty nine percent of patients had an abnormal cone off response. No patient had an abnormal cone off response at baseline. No patient with an abnormal cone off response recovered normal function. The cone off response could serve as a marker VGB retinal toxicity.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/31444 |
| Date | 20 December 2011 |
| Creators | Sienna, Julianna |
| Contributors | Westall, Carol |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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