Caffeine has been implicated in a number of health conditions, but the mechanisms and physiological pathways affected are not all well understood. Genetic variation in the caffeine metabolizing gene, CYP1A2 (rs762551), is associated with differences in caffeine metabolism and disease risk. The objectives of this thesis were to determine the association between caffeine intake and the plasma proteome and whether CYP1A2 genotype modifies any associations. Subjects (n=1095) were from the Toronto Nutrigenomics and Healthy Study. Initially, no significant associations were seen between caffeine intake and 54 high-abundance plasma proteins. After stratification by CYP1A2 genotype, plasma gelsolin levels decreased significantly with increasing caffeine intake among the slow metabolizers (A/C +C/C). These results suggest that plasma gelsolin levels are affected by caffeine intake and this association is only evident among slow metabolizers. Gelsolin may have a role in mediating some of the biological effects of caffeine.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/42955 |
| Date | 28 November 2013 |
| Creators | Tian, Ouxi |
| Contributors | El-Sohemy, Ahmed |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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