碩士 / 國立中山大學 / 海洋資源學系 / 83 / Bioassay directed screening indicated that the extract of
sponge Halicona sp.(SP134 sponge) possessed significant
cytotoxicity. The ethanolic extract of SP134 sponge was
fractionated by solvent partition,LH20 and silica gel
chromatography. As a reault,six cytotoxic compounds were
isolated, named SP a (manzamine A)(1),SP b(manzamine H)(5), SP
c(manzamine B)(2), SP d(manzamine D)(4),SP e(manzamine C)(3)
and SP f (keramaphidine B)(6),rspectively. Compounds 1-5
contain a common structure of β-carboline or 1,2,3,4-
tetrahydro-β-carboine moiety. Compound 6 which does not
contain β-carbiline moiety was considered to be the precursor
of manzamine alkaloids. The structures of compounds 1-6 were
established by UV,IR,MS,1D and 2D NMR technique. One the other
hand,in the study of the antitumor constituents terrestrial
plants, taxus mairei was selected as an experimental material.
To search for practical sources of potential useful taxoids and
study the structure and activity relationship of these compouds,
the ethanolic extract of the roots of Formosan Taxus mairei was
separated by extensive column and preparative thin layer
chromatography. As a result, 13 taxoids were isolated and their
structures were identified as 1-acetoxy-5-deacetylbaccatin I(19)
、taxinine J(22)、baccatin VI(26)、1-dehydroxybaccatin VI(27)、7
β,9α,10β,13α,20- pentaacetoxy-2α-benzoyloxy-4α,5α-
dihydroxytax-11-ene(29)、1- dehydroxybaccatin IV(36)、
Taxa-4(20),11-diene-5α,7β,9α, 10β ,13α-pentol-pentaacetate
(39)、2-deacetoxytaxinine J(43)、5α- hydroxy-7β,9α,10β,13α-
tetraacetoxy-taxa-4(20)、11-diene(44)、5α,7β,9α,10β,13α-
pentaacetoxy-20-benzoyloxy-2α,4α- dihydroxytax-11-ene(45)、1
β-acetoxy-5-deacetyl,7-deacetyl,9- deacetylbaccatin I(46)、10-
deacetyltaxol A(47)、10- deacetyltaxol C(48)。Among them,
compounds 44,45,and 46 were first isolated in nature and
compounds 47 and 48 were first isolated from T. mairei.
| Identifer | oai:union.ndltd.org:TW/083NSYSU277004 |
| Date | January 1995 |
| Creators | TAI,HUNG RU, 戴宏如 |
| Contributors | SHEN,YA CHING, 沈雅敬 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 142 |
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