碩士 / 國立中山大學 / 海洋資源學系 / 83 / The marine red alga Galaxaura marginata, obtained from the
coast of Oluanpi in southern Taiwan, was used as material in
this experiment. The chemical constituents and their
cytotoxicity were studied. The structures of eleven
constituents were elucidated by spectral analyses and organic
reactions. They are β -carotene (1), 24-dehydrocholesterol
(2), 24(R/S),25-epoxycholesterol (3), 24 ξ
-hydroperoxycholesta-5,25-dien-3 β -ol(4), 25-hydroperoxy
-cholesta-5,23(E)-dien-3β-ol (5), cholesta-5,25-dien-3β,24ξ-
diol (6), 24(R/S),25-epoxy-6β-hydroxycholesta-4-en-3-one (7),
24ξ-hydroperoxy-6β-hydroxycholesta-4,25-dien-3-one (8), 25-
hydroperoxy-6 β -hydroxycholesta-4,23(E)-dien-3-one (9), 24
ξ -hydroperoxycholesta-4, 25-dien-3, 6-dione
(10), and 25-hydroperoxycholesta-4,23(E)-dien-3,6-dione
(11). Epoxide 7 and hydroperoxides 4,5,8,9,10 and 11 were
isoolated from natural sources for the first time. This is
the first report regarding the isolation of hydroperoxysterol
from marine red algae. The cytotoxicity of the isolates
and their derivatives against P-388,KB,A-549,and HT-29
cancer cell lines were studied. Compound 1 exhibited selective
inhibition toward P-388 and HT-29 cell lines and compound 2
didn't show significant activity toward all of the above
cancer cell lines. Other metabolites and the dervatives
cholesta-5,23(E)-dien-3β,25-diol (12), 6β,24ξ-di-
hydroxycholesta-4, 25-dien-3-one (13),
25-dihydroxycholesta-4,23 (E)-dien-3-one (14), cholesta-4-3,6-
dione (15) and cholesta-4,25 -dien-3,6,24-trione (16)
exhibited significant cytotoxicities against the four cancer
cell lines (ED50<4.0μg/ml)
| Identifer | oai:union.ndltd.org:TW/083NSYSU277005 |
| Date | January 1995 |
| Creators | Huang, Shiang Yuh, 黃湘玉 |
| Contributors | Sheu, Jyh Horng, 許志宏 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 121 |
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