碩士 / 國立臺灣師範大學 / 家政教育研究所 / 87 / HRT(Hormone replacement therapy) might increase the risk of breast cancer,while fish oil seems to have protective effect against breast cancer. To investigate the effect of fish oil and HRT on the distribution of urinary estrogen metabolites in postmenopausal women, four groups of healthy postmenopausal women were recruited: (1) without HRT, non-HRT; (2) with HRT by taking estrogen only, HRT(E); (3) with HRT by taking estrogen and progestin, HRT(E+P) ; (4) 8 women with HRT were randomly chosen to take sunflower oil capsules as the placebo, HRT-SO. The first three groups were given 4g fish oil capsules per day (2g n-3 fatty acids) for 28 days. First morning urine samples were collected before and after oil supplementation, and the content of 2OHE1 and 16αOHE1 adjusted by creatinine and the ratio of 2OHE1 to 16αOHE1 (as an index of breast cancer risk) were measured. (1)Comparing the influence of HRT on estrogen metabolism before oil supplement, the data indicated that proportion of estrogen metabolized toward 2-hydroxylation was more in women with HRT than in those without HRT. Among the women taking HRT, urinary 16αOHE1 content was lower and 2OHE1/16αOHE1 ratio was higher in those taking estrogen than in those takiing combination of estrogen and progestin. (2)After fish oil supplementation, urinary 2OHE1/creatinine content , the percentage of 2OHE1 content in urinary 2OHE1 and 16αOHE1 and the ratio of 2OHE1 to 16αOHE1 decreased and reached a significant difference in HRT(E) and urinary 16αOHE1/creatinine, estriol/creatinine and TBARs/creatinine content increased compared with those before oil supplement but did not reach a significant difference.A significant negative correlation was found between the change of 2OHE1 and TBARs.In contrast, sunflower oil treatment induced the changes of above parameter in opposite dirrection. The results suggest that fish oil supplementation decreases the ratio of urinary 2OHE1 to 16αOHE1that might imply negative effect on the incidence of breast cancer.
| Identifer | oai:union.ndltd.org:TW/087NTNU0261009 |
| Date | January 1999 |
| Creators | Ling-Chun Li, 黎玲君 |
| Contributors | 吳文惠 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 101 |
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