碩士 / 國立臺灣大學 / 農業工程學研究所 / 87 / Uptake and depuration of dietary and waterborne 65Zn(II) were analyzed in aquacultural abalone Haliotis diversicolor supertexta and the red alga Gracilaria tenuistipitata var. liui using a simple first-order one-compartment bioaccumulation
model. A six-compartment physiologically based pharmacokinetic model of the disposition of Zn(II) in abalone key organs was developed to predict tissue distributions.
The one-compartment kinetic model was successfully fitted to determine uptake and depuration rate constants (i.e., k1 and k2, respectively) based on a 14-d exposure experiment. The resulting values of k1 and k2 of H. diversicolor supertexta were 101.4 ml g-1 d-1 and 0.611 d-1, respectively, when the abalone were exposed to 1 μg ml-1 Zn(II) seawater without the presence of G. tenuistipitata var. liui. When the abalone were fed with the algae, k1 and k2 values were estimated to be 114.5 g g-1 d-1 and 0.636 d-1, respectively. Bioconcentration factors (BCF) for the alga and abalone were determined to be 170 and 180, respectively; and the biomagnification factor (BMF) was 1.06 for the abalone. Both field and laboratory data show that BMF for Zn(II) were about 1. Further more, the abalone in the tank without algae absorbed the same quantity of Zn(II) as the abalone in the tank with alga. Results indicated that estimating uptake and depuration rates from depuration and short-term uptake experiments was a relizable means of predicting BCFss and BMFss, and we can conclude that Zn(II) in the abalone comes primarily from the ambient water and not from the algae. Model simulations using the six-compartment pharmacokinetic model for both water and food exposure routes indicated that the whole body Zn(II)
concentration was calculated to reach equilibrium in 10 days.Zn(II) however did not attain a steady-state in the soft tissue and the shell. It is concluded that a pharmacokinetic model is necessary for assessment of Zn(II) risk to abalone key tissues based on the Zn(II)-dynamics in target compartments.
| Identifer | oai:union.ndltd.org:TW/087NTU00404036 |
| Date | January 1999 |
| Creators | Bo-Ching Chen, 陳柏青 |
| Contributors | Chung-Min Liao, 廖中明 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 85 |
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