碩士 / 高雄醫學大學 / 行為科學研究所 / 88 / The life expectancy in Taiwan grows rapidly these years. The aged society has to face the problems of increasing prevalence and burdens of dementia, especially Alzheimer’s disease. Several researchers pointed out the close relation between Apolipoprotein E polymorphism and Alzheimer’s disease. The object of this paper is to address the clinical implication of Apo Eε4.
This research is case-control designed. We recruit 50 patients of Alzheimer’s disease from the out-patient department of a medical center in Taiwan. These patients meet the criteria of “definite dementia of Alzheimer’s type” and “probable dementia of Alzheimer’s types” of NINCDS-ADRDA and the criteria of “dementia of Alzheimer’s type” of DSM-IV. Another 50 persons were recruited as control group with sex- and age-matched. Each individual received the clinical interview. Basic data, MMSE scores, and blood samples for Apo E genotyping were collected then.
There are 28 females and 22 males in the case and control groups. Yet no significant difference of average age and educational levels are found between the two groups. The mean age of onset of Alzheimer’s disease is 72.62 y/o. The average interval between onset and research is 3.85 years. The mean MMSE scores differ significantly in these two groups (respectively 12.08, 24.56, p<0.0001). The Apo Eε4 allele frequencies is much more common in the case group (0.26) than control group (0.02, p<0.0001). Among the 50 cases, 12 were Apo Eε4-positive compared with 2 of the 50 controls. There was only one homozygote for Apo Eε4 in the case group but none among the controls. The odds ratio estimate was 7.6 (p < 0.001), suggesting that the presence of Apo Eε4 is significantly correlated with Alzheimer’s disease, especially in the late-onset Alzheimer’s disease, males, and those who received less education.
The clinical diagnosis, pharmaceutical studies, and genetic counseling of Alzheimer’s disease might benefit from the Apo E polymorphism. Further researches of Alzheimer’s disease with larger size of samples is suggested.
| Identifer | oai:union.ndltd.org:TW/088KMC00152026 |
| Date | January 2000 |
| Creators | Yung-Chieh Yen, 顏永杰 |
| Contributors | Mian-Yoon Chong, For-Way Lung, 張明永, 龍佛衛 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 70 |
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