碩士 / 國立中山大學 / 海洋資源學系研究所 / 88 / ABSTRACT
The marine sponge Xestospongia sp. was collected along seashore area of Lan Yu in Taiwan. Fractionation of the MeOH/CHCl3 extract by using silica gel colum chromatography yielded eight polycycle quinones and hydroquinones ,namely halenaquinone (1)、 halenaquinol(2)、14-methoxyxestoquinone (3)、15-methoxyxeatoquinone (4)、 xestoquinone (5)、15-chloro-hydroxestoquinone (6) 、adociaquinone A (7)、 adociaqunone B (8) . The structures of these compounds were idenified by UV、IR、MS、 1D and 2D NMR .
Biological screening revealed that compounds 7 and 8 possessed in vitro cytotoxicities against two tumor cell lines (KB 16, HEPA-3B). The ED50 value of compound 7 showed cytotoxicities against KB 16 and HEPA-3B tumor cell lines were 0.26 μg/mL and < 0.1 μg/mL, respectively. The ED50 value of compound 8 were < 0.1 μg/mL and 1.8 μg/mL .
| Identifer | oai:union.ndltd.org:TW/088NSYS5277018 |
| Date | January 2000 |
| Creators | Kuang-Liang Lo, 羅光良 |
| Contributors | none, 沈雅敬 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 50 |
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