碩士 / 國立中央大學 / 化學工程研究所 / 89 / Chitosan [β（1→4）-2-amino2-deoxy-D-glucan] is a nontoxic, biocomptible polymer and widely be used for wound dressing material. Three conditions of the experiment were employed: the different weight ratio and pH change of the polymer solution and crosslinking with calcium ion via different time. The homogeneous composite membrane consist of the porous structure which act as the water vapor barrier and is capable of absorbing wound exudate and provides a moist environment.
Due to the porous sponge structure of the composite membrane, oxygen could pass membrane completely and the membrane had better water uptaking ability, especially in pH change series. In vitro experiment, the composite membrane was nontoxic to the fibroblast cells and provided three-dimensional structure for cell growth and tissue repiration.
The release of AgSD from the composite membrane was slowly up to 14 days. Owing to the stronger bonding complex reaction the AgSD release of the pH series was slower than that the different weight ratio series. The antibacterial capacity of AgSD-impregnated wound dressing was examined in agar plate against Pseudomonas aeruginosa and Staphylococcus aureus. It was significantly found that the suppression of bacterial proliferation was effective within 7 days when compared with control group.
| Identifer | oai:union.ndltd.org:TW/089NCU00063047 |
| Date | January 2001 |
| Creators | 劉世明 |
| Contributors | 徐新興 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 74 |
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