碩士 / 國立臺灣大學 / 漁業科學研究所 / 89 / Abstract
Biogenic amines, dopa, dopamine, norepinephrine, epinephrine, octopamine, serotonin, and others, are widely distributed in the neural system and ganglia of crustaceans. They, as neurotransmitters and neuroregulators, are involved in regulating a wide spectrum of important physiological processes in organisms. Included are respiratory regulation, heart beating, glycemia, osmoregulation, hardening of exoskeleton, body coloration, immune and behavioral responses as well.
The physiological homeostasis and homeokinesis of animals are maintained through constant physiological compensation and regulation, which depend heavily on the sufficient supply of energy. Glucose, generally considered as an important energy sources in a variety of organisms and is frequently used as a biological indicator of the physiological conditions.
The objectives of the present research are aimed to clarify the modes and pathways of the actions of norepinephrine, epinephrine, dopamine and serotonin in the glycemic responses of Macrobrachium rosenbergii in vitro. The goal is approached by incubation of the hepatopancreas tissue with biogenic amine alone or with the combination of biogenic amine and its specific receptor antagonists, and the responses were monitored by quantifying the glucose content in the culture medium at 2 hr intervals. The culture medium and biogenic amines experimented are replenished at the same time. The results revealed that all the biogenic amines examined in this study, do enhance the glucose release from the hepatopancreas and muscular tissues. This suggests that the hyperglycemic response is not necessarily mediated through the actions of CHH, secreted and released from x-organ sinus gland complex. In the meantime, the hepatopancreas can be considered to be more important for the source of energy supply, when the glucose released at a specific dose is compared.
In addition, the pathways of the actions of the biogenic amines is summarized as follows: the actions is mediated through a1 and b1 for norepinephrine and epinephrine, and through D1 and 5-HT2 for dopamine and 5-HT, respectively. The pharmacological research strategies were followed in this study, and the antagonists employed were all developed in mammals. The homology of the receptors of NE, E, DA and 5-HT, and the affinity of antagonists to various receptors between the freshwater giant prawn and mammals are still unknown and remained for further elucidation.
| Identifer | oai:union.ndltd.org:TW/089NTU00451006 |
| Date | January 2001 |
| Creators | Yu Hwa Chen, 陳宥樺 |
| Contributors | Ching Ming Kuo, Wen Liang Liao, 郭欽明, 廖文亮 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 105 |
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