碩士 / 中國醫藥學院 / 醫學研究所 / 90 / Paeoniae radix has been used to relieve spasmodic abdominal pain in traditional Chinese medicine. Paeoniflorine, a major component from paeoniae radix, has several pharmacological effects including antiallergic, antinociceptive, antispasmodic and anti-inflammatory action.
In our previous studies, we found that paeoniflorin had antinociceptive effect on both formalin test and writhing response. Besides, paeoniflorin inhibited central excitatory behavior-induced by glutamate and NMDA etc. From our preliminary study, we found that paeoniflorin inhibited KCl-induced calcium influx in primary hippocampal cells. In this study KCl(100mM) and NMDA(125μM) were used to evoke calcium influx. Paeoniflorin pretreatment inhibited the calcium influx induced by KCl. The inhibition percentage was 33%. Whereas, paeoniflorin co administered with NMDA inhibited, the calcium influx evoked by NMDA. The inhibition percentage was 28.4%. Overloading of calcium causes neuronal cell death is reported by many authors. The inhibitor effect of paeoniflorin on KCl- or NMDA-induced calcium influx in neuronal cells implies that the availability of paeoniflorin on protection of neuronal cell death.
| Identifer | oai:union.ndltd.org:TW/090CMCH0534009 |
| Date | January 2003 |
| Creators | Chen Yi-Jui, 陳怡叡 |
| Contributors | Tsai Huei-Yann, Chen Yuh-Fung, 蔡輝彥, 陳玉芳 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 114 |
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