碩士 / 中國醫藥學院 / 藥物化學研究所 / 90 / 1. Studies on Antiallergic, Antiinflammatory and Antiproliferation Constituents of Helminthostachys zeylanica (L) Hook.
Four compounds and one mixure ――ß-sitosterol and stigmasterol (I), hexadecanoic acid (II), tetracosanoic acid (III), ugonin H (IV) and ugonin I (V), have been isolated from the n-hexane and chloroform fractions of the methanolic extract of Helminthostachys zeylanica (L) Hook. Among the isolated compounds, ugonin H (IV) and ugonin I (V) are isolated for the first time.
The results of the biological activities showed ugonin H (IV) and ugonin I (V) exhibited antiproliferation activities on U937 cells.
However, other compounds are still under test.
2. Studies on Differentiation-induced and Antiproliferation Constituents of Cryptomonadales
One compound and one mixture――bis-(2-ethylhexyl) phthalate (CPA-1), mixture of hexadecanoic acid and octadecanoic acid (CPA-2) have been isolated from the n-hexane, chloroform and ethyl aceteate fractions of the ethyl acetic extract of Cryptomonadales. These compounds were isolated for the first time from Cryptomonadales.
The results of the biological activity investigation showed bis-(2-ethylhexyl) phthalate (CPA-1) exhibited antiproliferation activities on U937 cells (IC50＝58.4 μg/ml).
| Identifer | oai:union.ndltd.org:TW/090CMCH0549012 |
| Date | January 2002 |
| Creators | Yaun-Chia Huang, 黃元照 |
| Contributors | Sheng-Chih Chen, Sheng-Chu Kuo, 陳勝智, 郭勝助 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 100 |
Page generated in 0.0019 seconds