碩士 / 國立海洋大學 / 食品科學系 / 90 / Abstract
The objectives of this study are to explore the rheological and gel formation properties of crude polysaccharide aqueous solution of Monostroma nitidum (aqueous solution) and it’s application in drug controlled release. The model drugs are Promethazine, Tolbutanide and Indomethacin. The study includes 1. To explore the effects of shear rate, solute concentration, solution pH, shearing time, boric acid concentration and boric acid in different pH solution on the rheological properties of aqueous solution; 2. To explore the effect of boric acid concentration, solution pH, sodium chloride concentration and calcium chloride concentration on the gel formation properties of aqueous solution; 3. To explore the effect of different matrixs made from aqueous solution and different parts (abdominal vs dorsal) of fresh skins of nude mice on the release rates of model drugs. The results obtained are as following:
The flow behavior of aqueous solutions are pseudoplastic fluid. Increasing the solute concentration enhanced shear thinning properties of those aqueous solutions. The apparent viscosity of different concentrations aqueous solution increased with increasing solution pH. The apparent viscosity of lower concentration aqueous solution decreased slightly with increasing shearing time but the high concentration one increased with shearing time. The apparent viscosity of aqueous solution increased with increasing boric acid concentration but at a concentration higher than 70 mM, the apparent viscosity decreased after shearing for certain period of time. The apparent viscosity of aqueous solution containing 40mM boric acid increased with increasing solution’s pH. The apparent viscosity of aqueous solution of pH 7 was higher than those either higher or lower solution pH ones.
Storage modulus of the gels prepared from aqueous solution containing 40mM boric acid at different solution pHs increased with increasing solution pH. Gel prepared from aqueous solution containing 40mM boric acid had higher storage modulus than those containing either higher or lower concentration of boric acid. Addition of sodium or calcium salts in the solution affected viscoelastic properties of the prepared gels. Sodium chloride concentration between 35-50 mM or calcium chloride concentration between 8.5-10.2 mM elevated gel’s storage module (G’) and lower its phase angle (tanδ). The elastic properties of the gel affected its water loss rate. The more elastic gel, the less water loss rate.
Release rate of model drugs of Promethazine、Tolbutanide、Indomethacin were faster in gel containing lower calcium chloride concentration and was lower to pass through fresh abdominal than through dorsal skin of nude mice. The results indicated that the structure of the matrix affected drugs release rate especial for those hydrophobic drugs.
| Identifer | oai:union.ndltd.org:TW/090NTOU0253022 |
| Date | January 2002 |
| Creators | CHEN YEN-CHIN, 陳彥景 |
| Contributors | R. H. CHEN, 陳榮輝 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 106 |
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