碩士 / 國立交通大學 / 環境工程所 / 91 / The effects on algal(Raphidocelis subcapitata) inhibition of 13 substituted anilines were recorded by using a close-system BOD bottle test, the mechanism of substituted anilines and chlorophenols were discussed which were both considered as polar narcotics.
The toxic test was ended based on DO and Biomass Methods. The Biomass Method was to calculate the cell density difference between the start and the final points. EC values were calculated using the appropriate model chosen from G-test. In this study, the toxic effects caused by substituted anilines were found to related to the numbers and positions of substitutents. With increasing of the substitutents, substances were found more toxic to algal. When compare with other species, BOD bottle test shows a similar sensitivity with Microtox and a good correlation was found in particular with another widely used assays system, the Tetrahymena assays. Quantitative structure-activity relationships (QSARs) were established between the EC50 values and various molecular descriptors for hydrophobic and hydrogen-bond interactions, and a highly predictive two-variable QSAR model was obtained.
In addition, a cut-off value approach is proposed to determine whether NOEC or EC10 should be chosen for estimating low toxic effects. The results indicate that NOEC offers better protection to test organisms than EC10.
| Identifer | oai:union.ndltd.org:TW/091NCTU0515017 |
| Date | January 2003 |
| Creators | Lee Po-Yi, 李柏逸 |
| Contributors | Chung- Yuan Chen, 陳重元 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 102 |
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