碩士 / 國立海洋大學 / 食品科學系 / 91 / Cholesterol was widely distributed in foods of animal origin, however there were usually to contain high dose of cholesterol and high dose of polyunsaturated fatty acid (PUFA) in marine foods, and furthermore there were also to contain taurine. When people make use of these kinds of marine foods, the oxidation of cholesterol and oil were not usually prevented. Some cholesterol oxides could cause harmful to our physiological reaction, and oxidized oil, too. On the other hand, it has been reported that taurine improves people who had hypercholesterolemia, and it also has the properties of antioxidant. Besides, it has be able to protect our liver against lipid peroxide. This prompted us to study the effect of taurine on the toxicity of oxidized cholesterol in rats, and then to investigate the effect of taurine on the toxicity of oxidized cholesterol and oxidized oil in rats.
In experimentⅠ, attempt was made to study the effect of taurine on the toxicity of oxidized cholesterol in rats. There were thirty rats divided into five groups. The diet regimen used in each group was as follows. Group A: rats were fed basal diet. Group B: rats were fed cholesterol diet. Group C: rats were fed cholesterol+taurine diet. Group D: rats were fed oxidized cholesterol diet. Group E: rats were fed oxidized cholesterol+taurine diet. After feeding diet for six weeks, we found that taurine could decrease the relative liver weight. Furthermore, it could reduce the activities of asparate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and the level of HDL-C (high density lipoprotein-cholesterol), LDL-C (low density lipoprotein-cholesterol), cholesterol, TG (triglyceride) and VLDL-C (very low density lipoprotein-cholesterol) in the plasma of rats. Similarly, taurine could depress thiobarbituric acid-reactive substances (TBARS) level and improve the glutathione (GSH) level in the liver of rats. It could ameliorate and prevent the harmful problem to the liver tissue section, too. Judging from these data, it indicated that taurine may play an important role in reducing the toxic effect of cholesterol and oxidized cholesterol in rats.
In experimentⅡ, we demonstrated the effect of taurine on the toxicity of oxidized cholesterol and oxidized fish oil in rats. There were also thirty rats divided into five groups. The diet regimen used in each group was as follows. Group A: rats were fed basal diet. Group B: rats were fed oxidized fish oil+cholesterol diet. Group C: rats were fed oxidized fish oil+cholesterol and taurine diet. Group D: rats were fed oxidized fish oil+oxidized cholesterol diet. Group E: rats were fed oxidized fish oil+oxidized cholesterol and taurine diet. After feeding diet for six weeks, we found that taurine could decrease the relative liver weight. Besides, it could reduce the activities of asparate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP) and the level of HDL-C (high density lipoprotein-cholesterol), LDL-C (low density lipoprotein-cholesterol), VLDL-C (very low density lipoprotein-cholesterol), cholesterol and TG (triglyceride) in the plasma of rats caused by oxidized oil or oxidized cholesterol. Similarly, taurine could depress thiobarbituric acid-reactive substances (TBARS) level and improve the glutathione (GSH) level in the liver of rats. It also could ameliorate and prevent the harmful problem to the liver tissue section. Judging from these data, it indicated that taurine may play an important role in reducing the toxic effect of oxidized oil and oxidized cholesterol in rats.
| Identifer | oai:union.ndltd.org:TW/091NTOU0253008 |
| Date | January 2003 |
| Creators | Ming Hsiung Chen, 陳名雄 |
| Contributors | Deng Fwu Hwang, 黃登福 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 99 |
Page generated in 0.0019 seconds