碩士 / 臺北醫學大學 / 生物醫學材料研究所 / 91 / Hemorheological studies were very important in the clinical development. Recently,microvascular abnormalities in Alzheimer’s disease is under intensive investigated.This study to evaluate the changes in hemorheological indexes for patients with Alzheimer’s disease and to discuss the mechanism of these changes and the effects in patients with Alzheimer’s disease.
Six elderly patients with Alzheimer’s disease and ten age-matched healthy subjects were included by evaluating the cognitive function of the Minimum Mental State Examination test (MMSE) . Fasting blood samples were collected to measure the biochemistries, complete blood counts and hemorheological indexes. Whole blood viscosity was measured in low, middle and high shear rate. Blood viscoelasticity was measured in oscillated model, Moreover,erythrocyte aggregation was measured in low shear rate.And plasma viscosity and erythrocyte deformability were measured in high shear. “Tk”level was calculated according to the equation {Tk= [(ηr0.4-1)/ηr0.4 ] / Hct } of Dintenfass.
The result revealed that there were significant different in all hemorheological indexes between Alzheimer’s disease group and control group except Hct and Tk level. Whole blood viscosity, plasma viscosity, viscoelasticity, plasma fibrinogen and erythrocyte aggregation of patients with Alzheimer’s disease group were significant higher than those of normal control group.Erythrocyte deformability of patients with Alzheimer’s disease was significant lower than healthy subjects. The increased erythrocyte aggregation duing low shear rate may due to the increased fibrinogen concentration.The decreased erythrocyte de- formability during high shear rate may result from membrane modification of erythrocyte.
| Identifer | oai:union.ndltd.org:TW/091TMC00684007 |
| Date | January 2003 |
| Creators | Szu-Ming Chen, 陳嗣民 |
| Contributors | Der-Zen Liu, 劉得任 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 1 |
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