碩士 / 國立交通大學 / 環境工程系所 / 92 / In this study, we use BOD bottles to perform a close-system algal(Raphidocelis subcapitata) test to assess the toxicity of two kinds of non-polar narcotic chemicals.
The comparison between the obtained EC50 values and toxicity data from the literature points out the good agreement between the BOD bottle test (Raphidocelis su.) and those of nine widely used test methods, i.e., Fathead minnow, Vibrio fi., Microtox, Polytox, Spriotox, Shk1, Activated sludge, Daphina ma. and Tetrahymena.
In this study, log Kow values of narcosis Ι compounds (using the BOD bottle test and nine bioassays) were reported. The toxicity data in our study and other bioassay have good correlation with log Kow value and also prove that there is well relationship between three endpoints. We developed a QSARs model to describe and predict the toxicity of industrial organic chemicals.
This assay is not only applicable for toxicity testing of single compounds. It can be also used for toxicity assessment of volatile fractions of environmental samples.
Our study shows that the additivity effects is the same as the literature for industrial chemical mixtures during the acute tests. A series of isobolograms were generated from this study. These diagrams were analyzed, through Multox model.fitting, to determine ρ and λ. For a single-species culture of organisms, ρ was found to be always 1, despite the type of chemicals involved. For two narcosisΙ toxicants, λ was approximately equal to 1, indicating similar mechanisms of toxicity.
The statistical analysis has provided a meaningful biological interpretation to the above model parameters.
| Identifer | oai:union.ndltd.org:TW/092NCTU5515006 |
| Date | January 2004 |
| Creators | Hsieh Shih-Hung, 謝適鴻 |
| Contributors | Chen Chung-Yuan, 陳重元 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 208 |
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