Chemical Constituents and Cytotoxicities of the Formosan Soft Corals Sarcophyton crassocaule, Tubipora musica Linneaus and Clavularia inflata / GN55肥厚肉質軟珊瑚、GN57笙珊瑚與GN63膨大羽珊瑚化學成分及癌細胞毒殺活性之研究

碩士 / 國立中山大學 / 海洋資源學系研究所 / 92 / Chromotographic separations of Formosan soft coral Sarcophyton crassocaule (GN-55) led to the isolations of four diterpenes, sarcophine (1), sarcophytoxide (2), (7R*, 8S*)-dihydroxysarcophytonin A (3), sarcophtonin A (4), one steroid, 17��,20��-epoxy-23,24- dimethyl-cholest-5- ene-3��,22-diol (5), and an eudesmane sesquiterpene, selin-11- en-4��-ol (6).
Two eudesmane epimers, 7 and 8 (new compound), three eudesmane sesquiterpenes, 9�{11, and a sphingolipid, 12 were isolated from Tubipora musica Linneaus (GN-57).
Chromotography of Clavularia inflata (GN-63) has led to the isolation of a new xenia diterpene, 13, (+)-ent-3��-hydroxyspathulenol ,15 , the new marine enantiomer to its territorial one, stolondiol monoacetate,14 , and 1��, 6��-dihydroxy-eudes-4,15-ene, 16, were isolated. The absolute structures of 13 and 15 were determined by MTPA esterifications. Cytotoxicities of these isolates against selected cancer cell lines were measured.

Identiferoai:union.ndltd.org:TW/092NSYS5277006
Date January 2004
CreatorsMingjae Huang, 黃敏捷
ContributorsC.-Y. Duh, 杜昌益
Source SetsNational Digital Library of Theses and Dissertations in Taiwan
Languagezh-TW
Detected LanguageEnglish
Type學位論文 ; thesis
Format247

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