碩士 / 國立中山大學 / 海洋資源學系研究所 / 92 / The chemical constituents of organic extracts of a Formosan soft coral Sinularia lochmodes (Kolonko) (collected at Ken-Ting in Taiwan) was studied and isolated twelve nature compounds (1–12), including seven new compounds, lochmodesolides A–E (1–5), 4,6-dibromo-(2'',5''-
dibromophenoxy) anisole (6), 3β,11-dihydroxy-5β,6β-expoxy-24-
methylene-9,11-secocholestan-9-one (7), and five know compounds (8–12),(1R*,5R*,8R*,10S*,11R*)-11-hydroxyl-1-isopropenyl-8-methyl-3,6-dioxo-5,8-epoxycyclotetradec-12-ene-10,12-carbolactone (8), (1R*,
5S*,8R*,10S*,11R*)-11-hydroxyl-1-isopropenyl-8-methyl-3,6-dioxo-5,
8-epoxycyclotetradec-12-ene-10,12-carbolactone (9), norcembrenolide 5 (10), scabrolides A (11), ineleganolide (12). The structures of 1–12 were elucidated by spectroscopic evidences (1D NMR, 2DNMR, IR and MS) and chemical method. The stereochemistry of compound 5 was further confirmed by single-crystal X-ray diffraction analyses.
Compounds 8 and 9 showed moderate cytotoxicity against KB, Hela, Med, NCI, DLD-1 and Hepa59T/VGH cancer cell lines.
| Identifer | oai:union.ndltd.org:TW/092NSYS5277010 |
| Date | January 2004 |
| Creators | Yen-ju Tseng, 曾彥儒 |
| Contributors | Jyh-horng Sheu, 許志宏 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 159 |
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