碩士 / 國立屏東科技大學 / 食品科學系 / 93 / The liver is the most important organ in the body involved in detoxification. It is in the liver where toxic substances such as drugs, alcohol, and environmental toxins, undergo a process called biotransformation which renders them less harmful and helps to facilitate their removal from the body. Liver detoxification involves a number of enzymatic systems which are divided into two general phases: Phase I and Phase II. Seaweeds administration was reported to enhance dioxin excretion and reduce dioxin absorption. Seaweeds were screened for their hepatoprotective activity using CCl4-induced liver injury in the rat as a model of chemical hepatitis. The aim of this study was to monitor the expression level of phase I and phase II enzyme coded genes by reverse transcription polymerase reaction (RT-PCR) and real-time polymerase reaction (Real-time PCR) in the liver of rats fed with Monostroma nitidum. No significant induction of GSTYa1, GSTYa2, NQO1 and CYP1A2 were observed. However, Monostroma nitidum was found to increase UGT1A1 and UGT1A6 mRNA levels and decrease CYP1A1 mRNA levels in rat liver.
| Identifer | oai:union.ndltd.org:TW/093NPUST253021 |
| Date | January 2005 |
| Creators | Zheng Kai Zhang, 張証凱 |
| Contributors | Tzou Chi Huang, 黃卓治 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 80 |
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