碩士 / 靜宜大學 / 資訊管理學系研究所 / 93 / Taiwan has been becoming an elderly society. According to the data publised on Feb. 2004 from Department of Social Affairs, Ministry of Interior indicated the population of individual age over 65 was up to 2.1 million, greater than 9.29%. The prevalence of dementia in the elderly society was about 2 to 4 % (around 42 and 84 thousands in Taiwan), in which the Alzheimer''s disease (AD) was about 50 to 90 %. In other words, there were about 21 to 75 thousands who suffered from dementia. Furthermore, the number of the dementia has increased about 15 thousands for each year. The cost of AD is huge including long–term medical and home care, as well as loss in quality of life. The main purpose of this study is to develop a computer program which assists diagnosis technique for AD based on magnetic resonance (MR) imaging.
In the study, there were five patients with AD and five healthy elderly volunteers to examine cognitive abilities screening instrument (CASI version C-2.0, 1997) and MR imaging diagnosis. The three dimensional MR Tl-weighted images of whole brain were acquired by a 1.5 T MR scanner (GE Singa Horizon LX). Through the comparison of the volumetric ratio between hippocampus and cerebrum, an index for the brain atrophy was found. By using the SPSS10.0 statistic analysis software, those are closely related to the non-demented one or demented one which were derived from CASI cutoff scores for different demographic groups.
Finally, we conclude that the relation between the AD and the index of the brain atrophy is significant. In future, it is possible to diagnose AD by using this medical image processing method which the only data for both volumes of hippocampus and cerebrum are needed.
Key word: Alzheimer''s disease; cognitive abilities screening instrument; magnetic resonance imaging; medical image processing; brain atrophy; hippocampus; Assisting the Diagnosis of Alzheimer''s Disease.
| Identifer | oai:union.ndltd.org:TW/093PU005396011 |
| Date | January 1900 |
| Creators | Chen-Hung Chen, 陳政宏 |
| Contributors | Yin-Te Tsai, Jr-Yuan Chiou, 蔡英徳, 邱志遠 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 57 |
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