碩士 / 長庚大學 / 基礎醫學研究所 / 94 / Enterovirus 71 (EV71) is a positive-stranded RNA virus in the genus Enterovirus of the family Picornaviridae. EV71 infection can cause hand, foot, and mouth disease (HFMD), herpangina and associated with fatal pulmonary edema as well as severe neurological complications, including encephalitis, meningitis, and a poliomyelitis-like syndrome in children. Several major outbreaks of EV71 have occurred in recent years in Taiwan. In this study we screened 22 Chinese medicine extracts for anti-EV71 activity. We found Houttuynia cordata Thunb. can neutralize the EV71-induced cytopathic effect (CPE) in Vero cells. The 50% inhibitory concentration of H. cordata on EV71 was approximately 125.92±27.837 g/mL. A plaque reduction assay showed that H. cordata can reduce the plaque formation. H. cordata was able to reduce viral protein synthesis and also abate the apoptotic process in enterovirus 71-infected Vero cells. We concluded that H. cordata possesses antiviral activity and has a potential for development as an anti-enterovirus 71 agent.
| Identifer | oai:union.ndltd.org:TW/094CGU00325058 |
| Date | January 2006 |
| Creators | Yi-Chun Liu, 劉怡君 |
| Contributors | , 陳君侃, 洪錦堂 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 68 |
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