碩士 / 嘉南藥理科技大學 / 生物科技研究所 / 94 / Morinda citrifolia, commonly known as noni, is reported to have anti-tumor, anti-viral and immune enhancing effects. A iridoid glycoside isolated from leaves of noni, is exhibited the inhibitory effect on AP-1 activity through the blocking of JNK mediated AP-1 phosphorylation. Epstein-Barr virus (EBV) is a human herpes virus. EBV infection causes nasopharyngeal carcinoma and lymphoma. Evidences showed that EBV lytic activation is attributed to ATF-2 and c-Jun phosphorylated by JNK, which activates Rta and Zta expression; Hence, noni may contain potential anti-EBV compounds. The purpose of this study is to analyze the efficacy of hot water and ethanolic extracts from leaves, green stems, brown stems and fruits against EBV Rta expression. This investigation used immunoblot assay to show the 90 % inhibitory activity of ethanolic extracts from leaves at concentration 400 �慊/ml。The Rta expression was fully inhibited by 600 �慊/ml ethanolic extracts from brown stems, green stems and fruits
| Identifer | oai:union.ndltd.org:TW/094CNUP5111031 |
| Date | January 2006 |
| Creators | Cheng-Shu Tasi, 蔡誠書 |
| Contributors | none, none, 林翠品, 葉東柏 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 48 |
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