碩士 / 國立臺灣大學 / 生理學研究所 / 94 / Background – Alzheimer’s disease is a progressing neurodegenerative disease characterized in short-term memory loss and associated with low docosahexaenoic acid (DHA, 22:6w3) in the hippocampus.
Aim – It is hypothesized that hippocampal DHA level could be manipulated by diets and associated with spatial learning memory performance studied by Morris’s water maze.
Design – Male rats was fed sunflower oil as ω3 deficient diet during brain development supplemented with or without fish oil to create various hippocampal DHA level. The animals at age of 100 days old performed the Morris water maze for learning ability and memory consolidation.
Outcomes – The hippocampal DHA level is created from 15% down to 5% of total fatty acid composition. The learning memory and memory retention is significant better in adult animals containing higher hippocampal DHA level compared with the reduced hippocampal DHA level. Compared to controls, the deficiency of DHA in hippocampus, olfactory bulb, frontal cortex and cerebellum can be recovery back to 91, 96, 64, 73%, respectively.
Conclusions – The hippocampal DHA level can be manipulated by diets, and be recovered back to normal from reduced DHA level in animals supplemented with fish oil. The learning memory performance is associated with hippocampal DHA level, and erythrocyte DHA level can be an index of hippocampal DHA level.
| Identifer | oai:union.ndltd.org:TW/094NTU05116007 |
| Date | January 2006 |
| Creators | Wan-ling Chung, 鍾宛伶 |
| Contributors | Hui-Min Su, 蘇慧敏 |
| Source Sets | National Digital Library of Theses and Dissertations in Taiwan |
| Language | zh-TW |
| Detected Language | English |
| Type | 學位論文 ; thesis |
| Format | 74 |
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